Publications
Purdom T, Wayland A, Nicoll, Justin X, Ludwar B, Fry A, Shanle EK^, Giles J. 2021. Intramuscular Hyaluronic Acid Expression Following Repetitive Power Training Induced Nonfunctional Overreaching. Applied Physiology, Nutrition, and Metabolism. Accepted.
Harris C*, Savas J*, Ray S, Shanle EK^. 2021. Yeast-based screening of cancer mutations in the DNA damage response protein Mre11. Molecular Biology Reports 1-13.
Slaughter MJ#, Shanle EK#^, Khan A, Chua KF, Allis CD, Josefowicz SZ, Garcia BA, Rothbart SB, Strahl BD, Davis IJ. 2021. HDAC inhibitors result in widespread alteration of the histone acetylation landscape and BRD4 retargeting to gene bodies. Cell Reports 34(3), 108638.
Shanle EK^ and Trubitsyn D. 2020. A Student-Focused Lab Module to Investigate Single-Nucleotide Polymorphisms of Common Heritable Traits. Journal of Microbiology & Biology Education, 21(3).
Slaughter MJ, Shanle EK, McFadden AW, Hollis ES, Suttle LE, Strahl BD, and Davis IJ. 2018. PBRM1 bromodomains variably influence nucleosome interactions and cellular function. Journal of Biological Chemistry 293 (35): 13592-13603.
Shanle EK#^, Shinsky SA#, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD. 2017. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics & Chromatin 10(1):12.
Savitsky P, Krojer T, Fujisawa T, Lambert J, Picaud S, Wang C, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl B, Gingras A, Filippakopoulos P. 2016. Multivalent histone and DNA engagement by the triple reader module of ZMYND8 directs the recruitment of a transcriptional network to genes to regulate gene expression. Cell Reports 17(10):2724-37.
Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK*, Krajewski K, Shi X, Strahl BD, Kutateladze TG. 2016. The Taf14 YEATS domain is a reader of histone crotonylation. Nat Chem Biol.12, 396-398.
Andrews FH#, Shanle EK#, Strahl BD, Kutateladze TG. 2016. The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation. Transcription 7, 14-20.
Shanle EK,Tsun I*, Strahl BD. 2015. A course-based undergraduate research experience investigating p300 bromodomain mutations. Biochem Mol Biol Ed 44, 68-74.
Shanle EK#, Andrews FH#, Meriesh H, McDaniel SL, Dronamraju R, DiFiore JV, Jha D, Wozniak GG, Bridgers JB*, Kerschner JL, Krajewski K, Mas Martin G, Morrison AJ, Kutateladze TG, Strahl BD. 2015. Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Genes Dev 29, 1795-1800.
Shanle EK, Onitilo A, Huang W, Kim K, Zang C, Champeny T, Engel J, Xu W, Wisinski K. 2015. Prognostic significance of full-length estrogen receptor beta expression in Stage I-III triple negative breast cancer. Am J Transl Res 7, 1246.
Rothbart SB, Dickson BM, Raab JR, Grzybowski AT, Krajewski K, Guo AH, Shanle EK, Josefowicz SZ, Fuchs SM, Allis CD, Magnuson TR, Ruthenburg AJ, Brian D. Strahl BD. 2015. An Interactive Database for the Assessment of Histone Antibody Specificity. Mol Cell 59, 502-511.
Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD. 2015. Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell 160, 204-218.
Shanle EK, Rothbart SB, Strahl BD. 2014. Chromatin biochemistry enters the next generation of code’seq-ing’. Nature methods 11, 799-800.
Shanle EK, Zhao Z, Hawse J, Keles S, Yuan M, Xu W. 2013. Research Resource: Global identification of estrogen receptor beta target genes in estrogen receptor alpha negative breast cancer cells. Mol Endocrinol 7, 1762-1775.
Sievers C#, Shanle EK#, Bradfield C, Xu W. 2013. Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β. Toxicol Sci 132, 359-367.
Yarger JG, Babine RE, Bittner M, Shanle EK, Xu W, Hershberger P, Nye SH. 2012. Structurally similar estradiol analogs uniquely alter the regulation of intracellular signaling pathways. J Mol Endocrinol 50, 43-57.
Shanle EK, Xu W. 2012. Function, expression, and detection of estrogen receptor isoforms in normal and malignant tissues, in: Chen, G. (Ed.), Estrogen Receptors: Mechanisms, Structure and Role in Disease. Nova Science Publishers Inc., New York, ISBN 978-1-62257-180-2. Book Chapter
Powell E, Shanle EK, Brinkman A, Li J, Keles S, Wisinski KB, Huang W, Xu W. 2012. Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ. PLoS One 7, e30993.
Shanle EK, Hawse JR, Xu W. 2011. Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands. Biochem Pharmacol 82, 1940-1949.
Shanle EK, Xu W. 2011. Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action. Chem Res Toxicol 24, 6-19. Review.
Shanle EK, Xu W. 2010. Selectively targeting estrogen receptors for cancer treatment. Adv Drug Deliv Rev 62, 1265-1276. Review.
Anterola AM, Shanle EK, Mansouri K, Schuette S, Renzaglia K. 2009. Gibberellin precursor is involved in spore germination in the moss Physcomitrella patens. Planta 229, 1003-1007.
Anterola AM, Shanle EK, Perroud PF, Quatrano R. 2009. Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens. Transgenic Res 18, 655-660.
Shanle EK, Anterola AM. 2008. Heterologous expression of a moss bifunctional kaurene synthase in E. coli. J Undergrad Chem Res 7, 85.Anterola AM, Shanle EK. 2008. Genomic insights in moss gibberellin biosynthesis. Bryologist 111, 218. Review.
*Undergraduate researchers; #Authors shared equal contributions; ^Longwood affiliation